Global AMR Surveillance Projects

About AMR surveillance projects

AMR surveillance projects is a database of current and past surveillance, and epidemiology of drug-resistant infections projects carried out by SEDRIC members. These projects cover a wide variety of topics, including, but not limited to surveillance, epidemiology, microbiology, mathematical modelling, diagnosis, data science, data governance, health systems, health policy, health economics, veterinary medicine, social science, policy development and public engagement.

How to submit an AMR surveillance project

Submit a project by completing the project submission form.

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Showing 4 out of 4 current projects
Molecular epidemiology of carbapenemase-producing Enterobacteriaceae isolates circulating in the public healthcare sector in KwaZulu-Natal, South Africa
01 September 2020 – 31 December 2023
South Africa

Topic(s) Epidemiology and surveillance, Microbiology, “One Health”

Author(s) Principal Investigator Dr Yogandree Ramsamy Co Investigators: Dr S Maphumulo, Dr R Singh, Dr A Niehaus, Dr NR Mvelase, Dr K Lutchminarain, Dr P Bhola, Dr P Ramjathan, Dr Y Mahabeer, Dr P Mahabeer, Dr S Haffejee, Dr L Sookan, Dr Khine Swe Swe Han (Senior Author, HoD)

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Project description
Multi-drug resistant organisms are a global phenomenon that threatens the future management of serious infections. The impact of these organisms could be catastrophic ultimately leading to a large number of deaths related to both community and hospital acquired infections. There is a definite concern that we a currently approaching an era of untreatable infections.
Aim of study
– To determine the molecular epidemiology of CRE and CPE in KZN?
– To perform molecular analysis on stored isolates to determine carbapenemase production.
– To perform molecular analysis on stored isolates to identify the type of carbapenemase produced.

Specific objectives
– To determine the molecular epidemiology of CPE from stored isolates in KZN (January 2016- December 2026)
– To determine the prevalence of CPE in a specific geographical population – i.e. determine the molecular epidemiology of CPE within KZN with regards to the most prevalent molecular type.

Study implications
– Provide scientific evidence to determine the molecular epidemiology and geographical distribution of CPE in KZN, South Africa.
– Will inform future antimicrobial prescribing practices. New antimicrobial agents are active against certain CPE molecular types.
Provide scientific evidence to design a diagnostic testing identifying CPE that is relevant to KZN.

Funding and affiliations
1. ISID-Pfizer AMS Grant Proposal
2. Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
National Health Laboratory Service, Durban, South Africa

Molecular Epidemiology and Antimicrobial Resistance Determinants of Neisseria gonorrhoeae in Kampala, Uganda
11 December 2019 – 30 June 2022
Uganda

Topic(s) Genomics, Epidemiology and surveillance

Project description
The project aim is to elucidate the genomic epidemiology and antimicrobial resistance determinants associated with NG among the strains circulating in Kampala Uganda. The specific aims are as follows;
• To describe the NG AMR Surveillance Programme in Kampala, Uganda and the emerging phenotypic antimicrobial susceptibility data generated using E-test
• To determine the genomic epidemiology of NG strains circulating in Kampala, Uganda using WGS and compare findings with behavioural, demographic and clinical data
• To identify the molecular AMR determinants associated with decreased susceptibility and/or resistance to NG using WGS and correlate with phenotypic data
Whole-genome sequencing of presumably the largest biorepository of NG isolates (n=1356) on the African continent will give an unprecedented snapshot into the genomic diversity of the organism in our settings and possibly unveil unknown AMR mechanisms.

Funding and affiliations
Infectious Diseases Institute, Makerere University Kampala Uganda
WHO Collaborating Centre for Gonorrhoea and other STIs, Orebro, Sweden

Antimicrobial Resistance in Communities and Hospitals in Kenya
01 October 2018 – 30 September 2021
Kenya

Topic(s) Epidemiology and surveillance

Author(s) Douglas R. Call, Sylvia Omulo, Ulzii-Orshikh Luvsansharav, Guy H. Palmer, Surie Diya, Rachel M. Smith

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Project description
The Antimicrobial Resistance in Communities and Hospitals (ARCH) study employs a cross-sectional design to investigate the prevalence and risk factors for colonization with multi-drug resistant organisms (MDRO) in the community and among hospitalized patients in urban and rural sites in Kenya. At these sites, 768 adults and 768 children are enrolled in the community, and 509 patients (total) are enrolled at hospital sites over a 12-month period. During enrollment, household and/or participant interviews are conducted and samples (stool/rectal swabs and nasal swabs) collected from consenting participants. Samples are tested for three MDROs i.e. extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESCrE) and carbapenem-resistant Enterobacteriaceae (CRE) from stool samples, and methicillin-resistant Staphylococcus aureus (MRSA) from nasal swabs. Study data will be analyzed to estimate the prevalence and risk factors for colonization with ESCrE, CRE and MRSA in these settings, and to determine the degree of genetic relatedness between MDROs in community and hospital sites.

Funding and affiliations
Funding institution
US Centers for Disease Control and Prevention

Collaborating institutions:
1. Centers for Disease Control and Prevention, Kenya
2. Kenya Medical Research Institute, Kenya
3. Ministry of Health, Kenya
4. University of Nairobi Institute of Tropical and Infectious Diseases, Kenya
5. US Centers for Disease Control and Prevention, US
6. Washington State University, US
7. Washington State University Global Health – Kenya, Kenya

The Fleming Fund
31 October 2017 – 31 October 2021
Ghana

Topic(s) Epidemiology and surveillance, Microbiology, Policy, “One Health”

Author(s) UK Department of Health & Social Care

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Project description
The Fleming Fund is a £265 million UK aid programme supporting up to 24 countries across Africa and Asia to tackle antimicrobial resistance. The Fund is managed by the Department of Health and Social Care and invests in strengthening surveillance systems through a portfolio of country and regional grants, global projects and fellowship schemes.

The UK Government established the programme in 2015 in response to the UK AMR Review and the WHO Global Action Plan on AMR, which called for funding to improve AMR surveillance, public awareness and responsible drug use. The programme focuses on low- and middle-income (LMIC) countries because they are expected to bear the heaviest consequences of the spread of AMR.

Our Aims
We build partnerships across sectors, governments and organisations
We equip countries to collect and use data on drug resistance
We encourage clinicians and farmers to use antibiotics better
We encourage governments to invest in tackling antimicrobial resistance for a sustainable future
We encourage policy makers to *make AMR a policy priority”

Funding and affiliations
The project is funded by UK aid, managed by the Department of Health and Social Care, in partnership with Mott MacDonald, the Management Agent.

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